2025 NFL OPOY Odds: Puka Nacua Holds Steady as Favorite

Philadelphia's Saquon Barkley's record-breaking season in 2024-25 earned him NFL Offensive Player of the Year honors.

But that was last season.

Could the Philly star be upended at the conclusion of this NFL campaign?

Let's check out the odds at DraftKings Sportsbook as of Oct. 7, as well as what to know about each leading candidate.

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2025-26 Offensive Player of the Year

Puka Nacua, WR, Rams: +250

What to know: L.A.'s Puka Nacua is holding steady as the favorite for Offensive Player of the Year. He has the most receptions (52) and receiving yards (588) in the NFL through five weeks. The Rams are 3-2, and despite DaVante Adams joining the squad, Nacua has established himself as the team's true No. 1 receiver. His odds surged from +850 after having a 170-yard receiving day in the Rams' Week 4 win over the Colts.

Jonathan Taylor, RB, Colts: +300

What to know: Colts' workhorse running back Jonathan Taylor has helped the team reach their surprising 4-1 record. His 480 yards on the ground are a league-best as are his six touchdowns.

Christian McCaffrey, RB, 49ers: +500

What to know: It's business as usual for dual-threat back McCaffrey. He has 282 rushing yards and 387 receiving yards through five weeks for the 4-1 49ers.

Bijan Robinson, RB, Falcons: +500

What to know: Through five weeks, Robinson has 314 rushing yards and 270 receiving yards — a true-dual threat back. But after his 75-yard rushing, 106-yard receiving Week 4 performance in the Falcons' win over Washington, his odds surged to +500 from +1000.

Amon-Ra St. Brown, WR, Lions: +1600

What to know: Brown's 35 receptions are tied for fourth in the NFL and his six TDs are best in the league. He also has 407 receiving yards on the season (fifth).

Jaxon Smith-Njigba, WR, Seahawks: +2000

What to know: Smith-Njigba has an incredible 534 receiving yards on the season, two TDs and 34 receptions (fifth). He's been targeted 43 times through five weeks.

Jahmyr Gibbs, RB, Lions: +2000

What to know: Gibbs, like St. Brown, is helping give Detroit's offense a boost. He's got four TDs and 325 rushing yards so far this season.

Justin Jefferson, WR, Vikings: +2500

What to know: Minnesota's star receiver only has one TD on the season, but he's got 449 receiving yards (third) for the 3-2 Vikes.

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