2025-26 Men's March Madness Odds: Purdue Favored; Arizona Makes a Leap

As every college football season creeps toward its end, a new college basketball season begins. 

Could the Florida Gators repeat? Will Purdue finally find its way to the top? Or can the Duke Blue Devils, with the top-ranked incoming recruiting class, emerge as champs?

Here’s a look at the odds from DraftKings Sportsbook as of Nov. 24.

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2025-26 Men's NCAA Tournament winner 

Purdue: +900 (bet $10 to win $100 total)
Duke: +950 (bet $10 to win $105 total)
Houston: +1000 (bet $10 to win $110 total)
UConn: +1200 (bet $10 to win $130 total)
Arizona: +1500 (bet $10 to win $160 total)
Kentucky: +1600 (bet $10 to win $170 total)
Louisville: +1600 (bet $10 to win $170 total)
Illinois: +1700 (bet $10 to win $180 total)
Gonzaga: +1800 (bet $10 to win $190 total)
Michigan: +1900 (bet $10 to win $190 total)
St. John's: +2000 (bet $10 to win $210 total)
Florida: +2200 (bet $10 to win $230 total)
BYU: +2200 (bet $10 to win $230 total)
Alabama: +2500 (bet $10 to win $260 total)

Here's what to know about the NCAA college hoops title oddsboard:

The Favorite(s): Early in the season, it's crowded atop the oddsboard, but Purdue is the new favorite, after Duke led a week ago. The Boilermakers (6-0) are the No. 1 team in the country and own wins over Alabama and Texas Tech. Meanwhile, Duke (7-0) is No. 5 in the country, also undefeated, and has wins over Texas and Kansas. Rounding out the top three is No. 2 Houston, which already has an early-season win over Auburn.

Making Moves: Arizona has had an impressive start to its season, with wins over Florida, UCLA and UConn in its first five games. It now sits fifth on the board, with matchups against Auburn and Alabama on the horizon.

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