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2025 NFL Odds Week 3: Lines, Spreads for all 16 Games
Published September 21, 2025
NFL Week 3 kicks off Thursday night, as the Buffalo Bills host the Miami Dolphins.
Here are the lines for every Week 3 matchup at DraftKings Sportsbook as of Sept. 21.
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(All times ET)
2025 NFL Week 3 Odds
THURSDAY, SEPT. 18
Point spread: Bills -12.5 (Dolphins cover)
Moneyline: Bills -850
Total Over/Under: 49.5 (Over hits)
SUNDAY, SEPT. 21
PACKERS @ BROWNS (1:00 p.m., FOX)
Point spread: Packers -8.5 (Packers favored to win by 8.5 points or more, otherwise Browns cover)
Moneyline: Packers -485 favorites to win; Browns +370 underdogs to win
Total Over/Under: 41.5 points scored by both teams combined
COLTS @ TITANS (1:00 p.m., CBS)
Point spread: Colts -5.5 (Colts favored to win by 5.5 points or more, otherwise Titans cover)
Moneyline: Colts -238 favorites to win; Titans +195 underdogs to win
Total Over/Under: 43.5 points scored by both teams combined
BENGALS @ VIKINGS (1:00 p.m., CBS)
Point spread: Vikings -3 (Vikings favored to win by 3 points or more, otherwise Bengals cover)
Moneyline: Vikings -166 favorites to win; Bengals +140 underdogs to win
Total Over/Under: 41.5 points scored by both teams combined
STEELERS @ PATRIOTS (1:00 p.m., CBS)
Point spread: Steelers -1.5 (Steelers favored to win by 1.5 points or more, otherwise Patriots cover)
Moneyline: Steelers -118 favorites to win; Patriots +102 underdogs to win
Total Over/Under: 44.5 points scored by both teams combined
RAMS @ EAGLES (1:00 p.m., FOX)
Point spread: Eagles -3.5 (Eagles favored to win by 3.5 points or more, otherwise Rams cover)
Moneyline: Eagles -198 favorites to win; Rams +164 underdogs to win
Total Over/Under: 45.5 points scored by both teams combined
JETS @ BUCCANEERS (1:00 p.m., FOX)
Point spread: Buccaneers -6.5 (Buccaneers favored to win by 6.5 points or more, otherwise Jets cover)
Moneyline: Buccaneers -340 favorites to win; Jets +270 underdogs to win
Total Over/Under: 43.5 points scored by both teams combined
RAIDERS @ COMMANDERS (1:00 p.m., FOX)
Point spread: Commanders -2.5 (Commanders favored to win by 3.5 points or more, otherwise Raiders cover)
Moneyline: Commanders -155 favorites to win; Raiders +130 underdogs to win
Total Over/Under: 43.5 points scored by both teams combined
FALCONS @ PANTHERS (1:00 p.m., FOX)
Point spread: Falcons -5.5 (Falcons favored to win by 5.5 points or more, otherwise Panthers cover)
Moneyline: Falcons -225 favorites to win; Panthers +185 underdogs to win
Total Over/Under: 44.5 points scored by both teams combined
TEXANS @ JAGUARS (1:00 p.m., CBS)
Point spread: Jaguars -1.5 (Jaguars favored to win by 1.5 points or more, otherwise Texans cover)
Moneyline: Jaguars -125 favorites to win; Texans +105 favorites to win
Total Over/Under: 43.5 points scored by both teams combined
BRONCOS @ CHARGERS (4:05 p.m., CBS)
Point spread: Chargers -2.5 (Chargers favored to win by 2.5 points or more, otherwise Broncos cover)
Moneyline: Chargers -155 favorites to win; Broncos +130 underdogs to win
Total Over/Under: 45.5 points scored by both teams combined
SAINTS @ SEAHAWKS (4:05 p.m., CBS)
Point spread: Seahawks -7.5 (Seahawks favored to win by 7.5 points or more, otherwise Saints cover)
Moneyline: Seahawks -375 favorites to win; Saints +295 underdogs to win
Total Over/Under: 41.5 points scored by both teams combined
COWBOYS @ BEARS (4:25 p.m., FOX)
Point spread: Cowboys -1.5 (Cowboys favored to win by 1.5 points or more, otherwise Bears cover)
Moneyline: Cowboys -125 favorites to win; Bears +105 underdogs to win
Total Over/Under: 49.5 points scored by both teams combined
CARDINALS @ 49ERS (4:25 p.m., FOX)
Point spread: 49ers -2.5 (49ers favored to win by 2.5 points or more, otherwise Cardinals cover)
Moneyline: 49ers -130 favorites to win; Cardinals +110 underdogs to win
Total Over/Under: 44.5 points scored by both teams combined
CHIEFS @ GIANTS (8:20 p.m., NBC)
Point spread: Chiefs -6 (Chiefs favored to win by 6 points or more, otherwise Giants cover)
Moneyline: Chiefs -305 favorites to win; Giants +245 underdogs to win
Total Over/Under: 44.5 points scored by both teams combined
MONDAY, SEPT. 22
LIONS @ RAVENS (8:15 p.m., ABC/ESPN)
Point spread: Ravens -4.5 (Ravens favored to win by 4.5 points or more, otherwise Lions cover)
Moneyline: Ravens -225 favorites to win; Lions +185 underdogs to win
Total Over/Under: 52.5 points scored by both teams combined
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